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300
syncytial virus is an important cause of community-
acquired lower respiratory infection among hospitalized
adults. J Infect Dis 1996; 174: 456-62.
6.- Thompson W W, Shay D K, Weintraub E,
Brammer L, Cox N, Anderson L J, et al. Mor-
tality associated with influenza and respiratory syncytial
virus in the United States. JAMA 2003; 289: 179-86.
7.- Garbino J, Gerbase M W, Wunderli W, De-
ffernez Ch, Thomas Y, Rocht T, et al. Lower
respiratory illnesses. Improved diagnosis by molecular
methods and clinical impact. Am J Respir Crit Care
Med 2004;170: 1197-203.
8.- Falsey A R, Hennessey P A, Formica M A,
Cox C, Walsh E E. Respiratory syncytial virus infec-
tion in elderly and high-risk adults. N Engl J Med 2005;
352: 1749-59.
9.- Lee N. High morbidity and mortality in adults hospi-
talized for respiratory syncytial virus infections. Clin
Infect Dis 2013; 57: 1069-77.
10.- Marcos M A, Campos M, Pimarola T, Mar-
tínez JA, Martínez E, Mensa J, et al. The
role of viruses in the aetiology of community-acquired
pneumonia in adults. Antiviral Therapy 2006; 11: 351-
9.
11.- van de Pol A C, van Loon A M, Wolfs T
F, Jansen N J, Nijhuis M, Bretelr E, et al.
Increased detection of Respiratory Syncytial Virus, in-
fluenza viruses, parainfluenza viruses and adenoviruses
with Real-Time PCR in samples from patients with res-
piratory symptoms. J Clin Microbiol 2007; 45: 2260-2.
12.- Welte T. Risk factors and severity scores in hospitali-
zed patients with community-acquired pneumonia: pre-
diction of severity and mortality. Eur J Clin Microbiol
Infect Dis 2011; 31: 33-47.
13.- van Kraij M G, van Elden L J, van Loon A
M, Hendriksen K A, Laterveer L, Dekker
A W, et al. Frequent detection of respiratory viruses in
adult recipients of stem cell transplants with the use of
Real-Time polymerase chain reaction, compared with
viral culture. Clin Infect Dis 2005; 40: 662-8.
14.- Gil R, Undurraga A, Saldías F, Jiménez
P, Barros M, et al. Estudio multicéntrico de factores
pronósticos en adultos hospitalizados por neumonía
adquirida en la comunidad. Rev Med Chile 2006; 134:
1357-66.
15.- Díaz A, Barría P O, Niederman M, Res-
trepo MI, Dreyse J, Fuentes G, et al. Etiology
of Community-acquired Pneumonia in Hospitalized
Patients in Chile. Chest 2007; 131:779-87.
16.- Jennings L C, Anderson T P, Beynon K A,
ChuaA, Laing R T R, Wemo A R, et al. Incidence
and characteristics of viral community-acquired pneu-
monia in adults. Thorax 2008; 63:42-8.
17.- Luchsinger V, Ruiz M, Zunino E, Martínez
M A, Machado C, Piedra PA, et al. Community-
acquired Pneumonia in Chile: the clinical relevance in
the detection of viruses and atypical bacteria. Thorax
2013; 68: 1000-6.
18.- Falsey A R, McElhaney J E, Beran J, van
Essen G A, Duval X, Esen M, et al. Respiratory
syncytial virus and other respiratory viral infections
in older adults with moderate to severe influenza-like
illness. J Infect Dis 2014; 209: 1873-8.
19.- McLellan J S, RayW C, Peeples M E. Structure
and function of RSV surface glycoproteins Curr Top
Microbiol Immunol 2013; 372: 83-104.
20.- Spann K M, Tran K C, Collins P L. Effect of
nonstructural proteins NS1 and NS2 of human respi-
ratory syncytial virus on interferon regulatory factor
3, NF-kappaB, and pro-inflammatory cytokines J Virol
2005; 79: 5353-62.
21.- Galiano M, Luchsinger V, Videla C, De
Souza L, Sánchez-Puch S, Ricarte C, et al.
Antigenic diversity within respiratory syncytial virus
strains isolated in Argentina and Chile. J Med Virol
2005; 77: 311-6.
22.- Luchsinger V, Elgueta A, Avendaño L F.
Respiratory Syncytial Virus genomic and antigenic va-
riants isolated in two pediatric hospitals in one season,
in Chile. J Clin Virol 2008; 42: 260-3.
23.- Imai T, HiesimaK, Haskell C, BabaM, Nagi-
ra M, Nishimura M, et al. Identification and mole-
cular characterization of fractalkine receptor CX3CR1,
which mediates both leukocyte migration and adhesion.
Cell 1997; 91: 521-30.
24.- Kurt-Jones E A, Popova L, Kwinn L, Haynes
L M, Jones L R, Tripp R A, et al. Pattern recog-
nition receptors TLR4 and CD14 mediate response
to respiratory syncytial virus. Nat Immunol 2000; 1:
398-401.
25.- Tayyari F, Marchant D, Moraes T J, Duan
W, Mastrangelo P, Hegele R G. Identification
of nucleolin as a cellular receptor for respiratory syn-
cytial virus. Nat Med 2011; 17: 1132-5.
26.- Stevenson M D, Mansbach J M Mowad E,
Dunn M, Clark S, Piedra PA SullivanA F, et
al Prenatal versus postnatal tobacco smoke and intensi-
ve care use in children hospitalized with bronchiolitis
Academic Pediatrics 2016; 16: 446-52.
27.- Jones L L, Hashim a, McKeever T, Cook
D G, Britton J, Leonardi-Bee J. Parental and
household smoking and the increased risk of bronchitis,
bronchiolitis and other lower respiratory infections in
infancy; systematic review and meta-analysis. Respire
Res 2011; 12: 5.
28.- , ,
eguimiento de lactantes hospitalizados por
bronquiolitis por virus respiratorio sincicial: Evolución
clínica, respuesta de atopia inflamatoria y marcadores.
Resultados preliminares Rev Chil Enf Respir 2016; 32:
18-24.
29.- Mansbach J M, Piedra PA, Stevenson M D,
P. V. Díaz A. et al.
Rev Chil Enferm Respir 2017; 33: 293-302