NEUMOLOGÍA PEDIÁTRICA

C o n t e n i d o d i s p o n i b l e e n h t t p : / / www. n e umo l o g i a - p e d i a t r i c a . cl 91 Neumol Pediatr 2019; 14 (2): 86 - 91 Bronquiectasia no fibrosis quística, desde la infancia hasta la adultez. Enfoque, diagnóstico y terapéutico mayoría. Pueden originarse en edades pediátricas o en el adulto. La bronquitis bacteriana persistente en niños se ha descrito como una causa probable del desarrollo de bronquiectasias no fibrosis quística en adultos. El tratamiento se basa en el manejo de los síntomas y la prevención de las exacerbaciones. La evidencia es escasa y la mayoría de las terapias se han investigado en las bronquiectasias tipo fibrosis quística. REFERENCIAS 1. Laënnec RTH. On mediate auscultation, or a treatise on the diagnosis of diseases of the lungs and heart. Paris: J.-A. Brosson et J.-S. Chaudé; 1819, 36 (2): 81-90. 2. Kapur N, Masel JP, Watson D, Masters IB, Chang AB. Bronchoarterial ratio on high resolution CT scan of the chest in children without pulmonary pathology – need to redefine bronchial dilatation. Chest 2011,139(6):1445-1450. 3. Matsuoka S, Uchiyama K, Shima H, Ueno N, Oish S, Nojiri Y.Bronchoarterial ratio and bronchial wall thickness on highresolution highresolution CT in asymptomatic subjects: correlation with age and smoking. Am. J. Roentgenol. 2003, 180(2):513-8. 4. Reid L. Reduction in bronchial subdivisions in bronchiectasis. Thorax. 1950;5:223–247. 5. Raghavan D, Jain R. Increasing awareness of sex differences in air-way diseases. Respirology 2016, Apr;21(3):449-59. 6. Quint J, Millett E, Joshi M, Navaratnam V, Thomas S, Hurst J, et al. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004. Eur Respir J. 2016 Jan;47(1):186-93. 7. Cereceda J, Samso C, Segura A, Sanhueza P. Bronquiectasias en adultos. Características clínicas Experiencia de 5 años 1998-2003. Rev Chil Enf Respir 2005; 21: 171-178 8. Diel, R, Ewing S, Blass S, et al. Incidence of patients with non-cystic fibrosis bronchiectasis in Germany – A healthcare insurance claims data analysis. Respir Med. 2019 May;151:121-127. 9. Goeminne PC, Scheers H, Decraene A, Seys S, Dupont LJ. Risk factors for morbidity and death in non–cystic fibrosis bronchiectasis: a retrospective cross-sectional analysis of CT diagnosed bronchiectatic patients. Respir Res 2012, Mar 16;13:21. 10. Cole PJ. Inflammation: a two-edged sword--the model of bronchiectasis. Eur J Respir Dis Suppl. 1986;147:6-15. 11. Whitwell F. A study of the pathology and pathogenesis of bronchiectasis. Thorax. 1952;7(3):213–239. 12. Marchant, JM, Masters, IB, Taylor, SM, Cox, NC, Seymour, GJ, Chang, AB. Evaluation and outcome of young children with chronic cough. Chest 2006; 129: 1132– 41. 13. Goyal V, Grimwood K, Marchant JM, Masters IB, Chang AB, Paediatric chronic suppurative lung disease: clinical characteristics and outcomes. Eur J Pediatr. 2016 Aug;175(8):1077-84. 14. Bush, A, Floto, RA. Pathophysiology, causes and genetics of paediatric and adult bronchiectasis. Respirology. 2019; 1– 10. https://doi-org.pucdechile.idm.oclc.org/10.1111/ resp.13509. [Epub ahead of print]. 15. King PT, Holdsworth SR, Freezer NJ, Villanueva E, Holmes PW. Characterisation of the onset and presenting clinical features of adult bronchiectasis. Respir. Med.2006, 100 (12): 2183 – 2189. 16. Martinez - Garcia, MA, Gracia, J, Vendrell Relat, M, Giron, RM, Maiz Carro, L, Rosa Carrillo, D,Olveira, C. Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score. Eur. Respir. J. 2014; 43: 1357– 67. 17. Moss R. Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Medical Mycology 2005: S203–S206. 18. Hart A, Sugumar K, Milan SJ, Fowler SJ, Crossingham I. Inhaled hyperosmolar agents for bronchiectasis. Cochrane Database of Systematic Reviews 2014, Issue 5. Art. No.: CD002996. DOI: 10.1002/14651858.CD002996.pub3. 19. Kapur N, Petsky HL, Bell S, Kolbe J, Chang AB. Inhaled corticosteroids for bronchiectasis. Cochrane Database of Systematic Reviews 2018. 16;5:CD000996. doi: 10.1002/14651858.CD000996.pub3. 20. Lee, Burge, Holland, Airway clearance techniques for bronchiectasis, Cochrane Database of Systematic Reviews, 2015 Nov 23;(11):CD008351. doi: 10.1002/14651858. CD008351.pub3. 21. Long-term macrolide maintenance therapy in non-CF bronchiectasis: Evidence and questions, Haworth, Charles S. et al., Respiratory Medicine, Volume 108, Issue 10, 1397 - 1408. 22. Trac MH, McArthur E, Jandoc R, et al. Macrolide antibiotics and the risk of ventricular arrhythmia in older adults. CMAJ. 2016;188(7):E120–E129. 23. Monteiro A, Stovold E, Zhang L. Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis: a systematic review European Respiratory Journal Aug 2014. European Respiratory Journal 2014 44: 382-393.